Simulation of red blood cell deformation and radial migration in microvessels
نویسندگان
چکیده
منابع مشابه
Computational Simulation of Red Blood Cell Deformation and Radial Migration in Microvessels
The motion and deformation of mammalian red blood cells (RBCs) in microvessels are simulated using a twodimensional computational model. Each RBC is represented as a set of interconnected viscoelastic elements suspended in a viscous fluid. The equations of equilibrium of this structure are solved simultaneously with the equations of fluid motion using a finite-element method. Computed cell shap...
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Red blood cell (RBC) migration effects and RBC-plasma interactions occurring in microvessel blood flow have been investigated numerically using a shear-induced particle migration model. The mathematical model is based on the momentum and continuity equations for the suspension flow and a constitutive equation accounting for the effects of shear-induced RBC migration in concentrated suspensions....
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A spring model is applied to simulate the skeleton structure of the red blood cell (RBC) membrane and to study the red blood cell (RBC) rheology in microvessels. The biconcave RBC shape in static plasma and tank-treading behavior of single cell in shear flows have been successfully captured in this model. The behavior of the RBC in a Poiseuille flow and the lateral migration of the cells in a s...
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The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50 μm, hematocrits from 20% to 45%, and shear rates from 20 to 150 s(-1) using a particle-based model with parallel computing. The apparent viscosity predicted by the simulation w...
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As endothelial cells are subject to flow shear stress. it is important to determine the detailed velocity distribution in microvessels in the study of mechanical interactions between blood and endothelium. Recently. particle image velocimetry (PIV) has been proposed as a quantitative method of measuring velocity fields instantaneously in experimental fluid mechanics. The authors have developed....
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a280-c